Chisa Yukizome begins her job as homeroom teacher for Hope's Peak Academy's 77th Class of Ultmate students. Meanwhile, Hajime Hinata, a student of the school's Reserve Course for students without talent, prepares to undergo an experiment to make him the Ultimate Hope. What follows is a series of tragic events which lead to the birth of the Remnants of Despair and the realisation of "The Biggest, Most Awful, Most Tragic Event in Human History."